TAXOL STRUCTURE-ACTIVITY-RELATIONSHIPS - SYNTHESIS AND BIOLOGICAL EVALUATION OF 2-DEOXYTAXOL

Authors
CHEN SH WEI JM FARINA V
Citation
Sh. Chen et al., TAXOL STRUCTURE-ACTIVITY-RELATIONSHIPS - SYNTHESIS AND BIOLOGICAL EVALUATION OF 2-DEOXYTAXOL, Tetrahedron letters, 34(20), 1993, pp. 3205-3206
Citations number
7
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
34
Issue
20
Year of publication
1993
Pages
3205 - 3206
Database
ISI
SICI code
0040-4039(1993)34:20<3205:TS-SAB>2.0.ZU;2-9
Abstract
2-Deoxy taxol 2 was prepared in nine steps from baccatin III; the key step of the synthesis is a Barton-type deoxygenation at C-2. The compo und was found to possess much reduced antitumor activity with respect to taxol.