TOTAL SYNTHESIS AND IONOPHORIC BEHAVIOR OF A GRAMICIDIN A ANALOG

Authors
CALMES M DAUNIS J DAVID D LAZARO R
Citation
M. Calmes et al., TOTAL SYNTHESIS AND IONOPHORIC BEHAVIOR OF A GRAMICIDIN A ANALOG, Tetrahedron letters, 34(20), 1993, pp. 3275-3278
Citations number
11
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
34
Issue
20
Year of publication
1993
Pages
3275 - 3278
Database
ISI
SICI code
0040-4039(1993)34:20<3275:TSAIBO>2.0.ZU;2-4
Abstract
A new gramicidin A analogue (GAA) containing a C-terminal P-alaninamid e group instead of the natural ethanolamine moiety has been synthesize d on a polyacrylic resin and examined after its incorporation into a b lack lipid membrane (BLM). Preliminary conductance data show that this peptide and the natural gramicidin both display the same ionophoric a ctivity.