STUDIES TOWARDS THE SYNTHESIS OF THE SATURATED AND UNSATURATED CARBOCYCLIC METHYLENE PHOSPHONATE ANALOGS OF DIDEOXYADENOSINE

Authors
WOLFFKUGEL D HALAZY S
Citation
D. Wolffkugel et S. Halazy, STUDIES TOWARDS THE SYNTHESIS OF THE SATURATED AND UNSATURATED CARBOCYCLIC METHYLENE PHOSPHONATE ANALOGS OF DIDEOXYADENOSINE, Nucleosides & nucleotides, 12(3-4), 1993, pp. 279-294
Citations number
29
Categorie Soggetti
Biology
Journal title
Nucleosides & nucleotides → ACNP
ISSN journal
07328311
Volume
12
Issue
3-4
Year of publication
1993
Pages
279 - 294
Database
ISI
SICI code
0732-8311(1993)12:3-4<279:STTSOT>2.0.ZU;2-M
Abstract
The synthesis of the saturated carbocyclic methylene phosphonate analo g of ddAMP is described by two different methods (epoxyde opening and ''purinoselenylation''). Studies towards the formation of 2',3' unsatu rated analogs by selenoxyde or mesylate elimination are also reported.