AUTOMATED SYNTHESIS OF CYCLIC OLIGODEOXYRIBONUCLEOTIDES VIA PHOSPHORAMIDITE METHOD

Authors
CONTE MR MAYOL L MONTESARCHIO D PICCIALLI G SANTACROCE C
Citation
Mr. Conte et al., AUTOMATED SYNTHESIS OF CYCLIC OLIGODEOXYRIBONUCLEOTIDES VIA PHOSPHORAMIDITE METHOD, Nucleosides & nucleotides, 12(3-4), 1993, pp. 351-358
Citations number
15
Categorie Soggetti
Biology
Journal title
Nucleosides & nucleotides → ACNP
ISSN journal
07328311
Volume
12
Issue
3-4
Year of publication
1993
Pages
351 - 358
Database
ISI
SICI code
0732-8311(1993)12:3-4<351:ASOCOV>2.0.ZU;2-T
Abstract
The functionalized polyethylene glycol/polystyrene copolymer support 4 was shown to be suitable for a completely automated synthesis of smal l- to medium-sized cyclic oligodeoxyribonucleotides. Syntheses of the linear precursors were achieved by the phosphoramidite method, whereas the cyclization reactions were based on the phosphotriester chemistry .