A NEW FACILE SYNTHESIS AND ANTIVIRAL ACTIVITY OF OXAZOFURIN

Authors
FRANCHETTI P MESSINI L CAPPELLACCI L GRIFANTINI M GUARRACINO P MARONGIU ME PIRAS G LACOLLA P
Citation
P. Franchetti et al., A NEW FACILE SYNTHESIS AND ANTIVIRAL ACTIVITY OF OXAZOFURIN, Nucleosides & nucleotides, 12(3-4), 1993, pp. 359-368
Citations number
19
Categorie Soggetti
Biology
Journal title
Nucleosides & nucleotides → ACNP
ISSN journal
07328311
Volume
12
Issue
3-4
Year of publication
1993
Pages
359 - 368
Database
ISI
SICI code
0732-8311(1993)12:3-4<359:ANFSAA>2.0.ZU;2-0
Abstract
A new, more facile synthesis of oxazofurin, a structural analogue of t iazofurin, selenazofurin and ribavirin, has been carried out by rhodiu m catalyzed reaction of ethyl alpha-formyl-diazoacetate with 2,3,5-tri -O-benzoyl-beta-D-ribofu-ranosyl cyanide. When evaluated against DNA a nd RNA viruses, HIV-1 inclu-ded, oxazofurin was found inactive. It was also ineffective in potentiating the anti-HIV activity of 2',3'-dideo xyadenosine.