SYNTHESIS OF SEVERAL 2'-DEOXY-3-ALKYL(ARYL)-3-DEAZAGUANOSINES - MILD ALKYLATION OF A CYANOMETHYL IMIDAZOLE WITH ELECTROPHILES

Authors
ACEVEDO OL ANDREWS RS COOK PD
Citation
Ol. Acevedo et al., SYNTHESIS OF SEVERAL 2'-DEOXY-3-ALKYL(ARYL)-3-DEAZAGUANOSINES - MILD ALKYLATION OF A CYANOMETHYL IMIDAZOLE WITH ELECTROPHILES, Nucleosides & nucleotides, 12(3-4), 1993, pp. 403-416
Citations number
20
Categorie Soggetti
Biology
Journal title
Nucleosides & nucleotides → ACNP
ISSN journal
07328311
Volume
12
Issue
3-4
Year of publication
1993
Pages
403 - 416
Database
ISI
SICI code
0732-8311(1993)12:3-4<403:SOS2-M>2.0.ZU;2-2
Abstract
The synthesis of several 2'-deoxy-3-alkyl(aryl)-3-deazaguanosines and of their heterocyclic aglycone is described. The 2-(1-napthyl)ethyl su bstituent group induces an unnatural 3'-endo/high-anti (-sc) conformat ion of the nucleoside.