Ol. Acevedo et al., SYNTHESIS OF SEVERAL 2'-DEOXY-3-ALKYL(ARYL)-3-DEAZAGUANOSINES - MILD ALKYLATION OF A CYANOMETHYL IMIDAZOLE WITH ELECTROPHILES, Nucleosides & nucleotides, 12(3-4), 1993, pp. 403-416
The synthesis of several 2'-deoxy-3-alkyl(aryl)-3-deazaguanosines and
of their heterocyclic aglycone is described. The 2-(1-napthyl)ethyl su
bstituent group induces an unnatural 3'-endo/high-anti (-sc) conformat
ion of the nucleoside.