SYNTHESIS OF CHIRAL 3-SUBSTITUTED 2,4(1H,3H)-QUINAZOLINEDIONES

Authors
CANONNE P AKSSIRA M DAHDOUH A KASMI H BOUMZEBRA M
Citation
P. Canonne et al., SYNTHESIS OF CHIRAL 3-SUBSTITUTED 2,4(1H,3H)-QUINAZOLINEDIONES, Heterocycles, 36(6), 1993, pp. 1305-1314
Citations number
19
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Heterocycles → ACNP
ISSN journal
03855414
Volume
36
Issue
6
Year of publication
1993
Pages
1305 - 1314
Database
ISI
SICI code
0385-5414(1993)36:6<1305:SOC32>2.0.ZU;2-J
Abstract
2-Carbomethoxyphenyl isocyanate and 6-nitro-2-carbomethoxyphenyl isocy anate were generated in situ from half-esters, and then converted into the corresponding quinazolinediones using alpha-amino acids. This use ful annelation process was found to be a general method for the format ion of various chiral 3-substituted quinazolinediones.