RENAL-FUNCTION ABNORMALITIES AFTER IFOSFAMIDE TREATMENT IN CHILDREN

Renal function was evaluated in 12 children (aged 2.5-17.5 years) who received ifosfamide as part of their chemotherapy for different malign ancies. A blood and urine analysis evaluating renal glomerular and tub ular function and an isotopic determination of glomerular filtration w ere carried out four months or later after treatment had been stopped. Three patients had several biochemical abnormalities suggesting a sig nificant degree of proximal renal dysfunction (increased urinary excre tion of calcium, glucose, beta 2-microglobulin, amino acids (three pat ients) and decreased tubular reabsorption of phosphate (one patient)). The tubular dysfunction in these patients was associated with a dimin ished glomerular filtration. These patients could be characterized by their younger age at treatment and a higher dose of ifosfamide receive d if calculated per kg body weight.