PLASMA BEVANTOLOL CONCENTRATION AND HEART-RATE IN RABBITS

Bevantolol (Bev, 5, 10 mg . kg-1) was injected iv to rabbits. A measur e the lag time of heart rate (HR) response behind the changes in plasm a Bev concentrantion (K(eo)) and the sensitivity of the site of action of Bev (EC50) were determined. The K(eo) were 0.03 +/- 0.02 and 0.029 +/- 0.009 min-1 and the EC50) were 0.2 +/- 0.1 and 0.27 +/- 0.14 mug . ml-1 respectively for the 2 dosages. The peak changes in HR lagged b ehind the changes in plasma Bev concentration. There were no significa nt changes in both pharmacokinetic and pharmacodynamic parameters betw een the 2 dosages.