PROTECTIVE EFFECTS OF 3, 6-DIMETHYLAMINODIBENZOPYRIODONIUM EDETATE ONGLOBAL-ISCHEMIA REPERFUSED ISOLATED RAT HEARTS

The effects of 3,6-dimethylamino-dibenzopyriodonium edetate (IHC-72) o n global ischemia reperfused rat hearts were investigated. In the isol ated working rat heart, 40-min global ischemia followed by 30-min repe rfusion resulted in increases of ventricular tachycardia (VT) and vent ricular fibrillation (VF), increases of creatine kinase (CK) release a nd malondialdehyde (MDA) contents, but decreased superoxide dismutase (SOD) activity. Following ischemia and reperfusion, the accumulation o f myocardial calcium increased. IHC-72 50 mumol . L-1 given 10 min bef ore ischemia and during reperfusion decreased the cardiac CK release, VT, and VF, reduced the MDA contents, prevented the reduction of SOD a ctivity and attenuated the accumulation of myocardial calcium and sodi um vs control. These results indicated that IHC-72 protected myocardia l reperfused injury.