PHARMACOKINETICS AND RELATIVE BIOAVAILABILITY OF LOMEFLOXACIN PREPARATIONS IN 10 HEALTHY CHINESE VOLUNTEERS

The pharmacokinetics of lomefloxacin tablet and capsule were determine d following a single oral dose of 400 mg given to each of 10 Chinese h ealthy male volunteers in an open, randomized crossover study. Drug co ncentrations in plasma were assayed by HPLC method. The peak levels in plasma averaged 6.0+/-1.3 and 5.9+/-1.0 mug . ml-1 at 1.3 +/-0.4 and 1.2+/-0.4 h , and the areas under the drug concentration curves were 4 3+/-15 and 44+/-13 h . mug . ml-1 for lomefloxacin tablet and capsule, respectively. the concentration-time courses after medication conform ed to a l-compartment open model with a first order absorption. Pharma cokinetic parameters after tablet did not differ significantly from th e corresponding values after capsule. the bioavailability of tablet wa s comparable to that of capsule.