PHARMACOKINETICS AND PHARMACODYNAMICS OF 2 MORPHOLOGICALLY HOMOGENOUSFORMS OF FAMOTIDINE PER OS IN CHINESE HEALTHY-VOLUNTEERS

The lg C of famotidine (Fam) A and B forms in plasma vs time curve fol lowing a single oral dose of 40 mg showed an one-compartment open mode l in 5 healthy volunteers. The T1/2Ke of Fam A and B forms = 3.06 and 3.48 h, T(max) = 2.96 and 2.68 h, The C(max) = 115 and 145 ng . ml-1, AUC = 811 and 1190 h . ng . ml-1, respectively. No significant differe nce was found in the pharmacokinetic and pharmacodynamic properties be tween Fam A and B forms. The mathematical model describing the whole c ourse of blood concentration of Fam A and B forms in relation to inhib iting effects on gastric acid were: E (A) = 100 . C2.04/(C2.04 + 15.0( 2.04)) and E (B) = 100 . C1-67/ (C1.67 + 14.0(1.67)). Predication of b lood drug concentration from pharmacodynamics or vice versa became pos sible using the mathematical equations.