ANTICONVULSANT ACTIVITY OF THE GAMMA-AMINOBUTYRIC-ACID UPTAKE INHIBITOR NYL-4,5,6,7-TETRAHYDROISOXAZOLO[4,5-C]PYRIDIN-3-OL

Authors
WHITE HS HUNT J WOLF HH SWINYARD EA FALCH E KROGSGAARDLARSEN P SCHOUSBOE A
Citation
Hs. White et al., ANTICONVULSANT ACTIVITY OF THE GAMMA-AMINOBUTYRIC-ACID UPTAKE INHIBITOR NYL-4,5,6,7-TETRAHYDROISOXAZOLO[4,5-C]PYRIDIN-3-OL, European journal of pharmacology, 236(1), 1993, pp. 147-149
Citations number
8
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
European journal of pharmacology → ACNP
ISSN journal
00142999
Volume
236
Issue
1
Year of publication
1993
Pages
147 - 149
Database
ISI
SICI code
0014-2999(1993)236:1<147:AAOTGU>2.0.ZU;2-S
Abstract
The N-4,4-diphenyl-3-butenyl derivative of the glial selective gamma-a minobutyric acid (GABA) uptake inhibitor 4,5,6,7-tetrahydroisoxazolo[4 ,5c]pyridin-3-ol (N-DPB-THPO), was tested for its ability to block sou nd-induced seizures in the audiogenic seizure-susceptible Frings mouse model of epilepsy. Following intracerebroventricular (i.c.v.) adminis tration, N-DPB-THPO blocked tonic hindlimb extension in a dose- and ti me-dependent manner. At the doses tested no gross behavioral effects w ere noted.