ANTI-GAMMA-GLOBULIN FACTORS IN HUMAN SERA REVEALED BY ENZYMATIC SPLITTING OF ANTI-RH ANTIBODIES - COMMENTARY

Authors
OSTERLAND CK HARBOE M KUNKEL HG
Citation
Ck. Osterland et al., ANTI-GAMMA-GLOBULIN FACTORS IN HUMAN SERA REVEALED BY ENZYMATIC SPLITTING OF ANTI-RH ANTIBODIES - COMMENTARY, Vox sanguinis, 64(4), 1993, pp. 246-247
Citations number
9
Categorie Soggetti
Hematology
Journal title
Vox sanguinis → ACNP
ISSN journal
00429007
Volume
64
Issue
4
Year of publication
1993
Pages
246 - 247
Database
ISI
SICI code
0042-9007(1993)64:4<246:AFIHSR>2.0.ZU;2-T
Abstract
Human sera were found that contained antibody activity which caused ag glutination of red cells or particles sensitized with immunoglobulin G that had first been degraded by pepsin proteolysis. The agglutinating activity was specific for a determinant that was not present on the u ntreated, native immunoglobulin. It was found most frequently in sera from rheumatoid arthritis patients and its titre showed some correlati on with disease activity.