Sn. Dube et al., ROUTE-SPECIFIC CARDIORESPIRATORY AND NEUROMUSCULAR CHANGES FOLLOWING ORGANOPHOSPHOROUS POISONING IN RATS, Archives internationales de pharmacodynamie et de therapie, 321, 1993, pp. 112-122
Organophosphorous compounds cause a variety of physiological effects.
The effect of various routes of administration of these compounds on t
he pathophysiology is still an open question. The present study addres
ses the effect of two organophosphorous compounds, namely diisopropyl
fluorophosphate and methyl-isopropyl phosphonofluoridate, given by two
different routes (i.v. and s.c.), on physiological parameters in anae
sthetized and artificially ventilated rats. Both organophosphorous com
pounds produced a dose-dependent rise in blood pressure, bradycardia a
nd twitch potentiation after i.v. administration. These effects are me
diated by muscarinic as well as alpha-adrenoreceptors and are not affe
cted by adrenalectomy. However, after s.c. administration, both organo
phosphorous compounds produced a dose-dependent transient hypotension
and bradycardia, mediated by muscarinic receptors, without affecting o
ther physiological parameters. The results indicate the route-specific
effects of these compounds on the cholinergic-catecholaminergic inter
actions in rats.