TAMOXIFEN INHIBITS LIPID-PEROXIDATION IN CARDIAC-MICROSOMES - COMPARISON WITH LIVER-MICROSOMES AND POTENTIAL RELEVANCE TO THE CARDIOVASCULAR BENEFITS ASSOCIATED WITH CANCER PREVENTION AND TREATMENT BY TAMOXIFEN
H. Wiseman et al., TAMOXIFEN INHIBITS LIPID-PEROXIDATION IN CARDIAC-MICROSOMES - COMPARISON WITH LIVER-MICROSOMES AND POTENTIAL RELEVANCE TO THE CARDIOVASCULAR BENEFITS ASSOCIATED WITH CANCER PREVENTION AND TREATMENT BY TAMOXIFEN, Biochemical pharmacology, 45(9), 1993, pp. 1851-1855
Tamoxifen and 4-hydroxytamoxifen were both good inhibitors of iron-dep
endent lipid peroxidation in rat cardiac microsomes. Tamoxifen was als
o a good inhibitor of lipid peroxidation in liposomes prepared from th
e phospholipid obtained from rat liver microsomes. In a modified rat l
iver microsomal system containing a sufficiently low amount of peroxid
izable phospholipid to make it comparable with the rat cardiac microso
mal system, tamoxifen and 4-hydroxytamoxifen were of similar effective
ness as in the cardiac system. Tamoxifen is known to lower serum chole
sterol levels, and the findings reported here indicate that the drug m
ight also protect heart cell membranes against peroxidative damage. Po
tential cardioprotective and antiatherosclerotic benefits of tamoxifen
are discussed in relation to the drug's use in cancer prevention and
treatment.