EFFECT OF FAMOTIDINE ON RENAL-TRANSPLANT PATIENTS TREATED WITH CYCLOSPORINE-A

The influence of a 7-day course of 40 mg famotidine administered orall y on the pharmacokinetics of ciclosporine A at steady-state has been i nvestigated in 10 renal transplant patients. Famotidine did not appear to significantly alter the pharmacokinetics of ciclosporine A. This m ight be ascribed to the limited potential of famotidine for inhibiting microsomal enzyme function. Moreover, plasma creatinine concentration s and creatinine clearance remained stable. Our results suggest that f amotidine has no noticeable interaction with ciclosporine A.