SYNTHESIS OF 3-(BETA-D-RIBOFURANOSYL)PYRAZOLO[3,2-I]-PURINE DERIVATIVES AND THEIR CYTOTOXIC ACTIVITIES

Authors
HAMAMICHI N MIYASAKA T
Citation
N. Hamamichi et T. Miyasaka, SYNTHESIS OF 3-(BETA-D-RIBOFURANOSYL)PYRAZOLO[3,2-I]-PURINE DERIVATIVES AND THEIR CYTOTOXIC ACTIVITIES, Journal of heterocyclic chemistry, 30(2), 1993, pp. 313-315
Citations number
7
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Journal of heterocyclic chemistry → ACNP
ISSN journal
0022152X
Volume
30
Issue
2
Year of publication
1993
Pages
313 - 315
Database
ISI
SICI code
0022-152X(1993)30:2<313:SO3D>2.0.ZU;2-O
Abstract
mino-3-(beta-D-ribofuranosyl)pyrazolo[3,2-i]purine (6) has been prepar ed from a fully protected 3,(beta-D-ribofuranosyl)pyrazolo[3,2-i]purin e (2) and the 9-bromo substituted derivative 3 by nitration, followed by re. duction. Reaction of romo-3-(beta-D-ribofuranosyl)pyrazolo[3,2- i]purine (1b) with alkali gave the (pyrazol-3-yl)imidazole derivative, followed by diazocyclization with sodium nitrate to give syl)imidazol o[4,5-d]pyrazolo[2,3-c][1,2,3]triazine (10) after deacetylation. Compo unds 6 and 10 exhibited cytotoxic activity against leukemia cells.