PREPARATION OF NOVEL 1,2,4-THIADIAZOLES BY CYCLIZATION WITH 4-METHYLBENZENESULFONYL CYANIDE (TOSYL CYANIDE) [1]

Authors
UNANGST PC SHRUM GP CONNOR DT
Citation
Pc. Unangst et al., PREPARATION OF NOVEL 1,2,4-THIADIAZOLES BY CYCLIZATION WITH 4-METHYLBENZENESULFONYL CYANIDE (TOSYL CYANIDE) [1], Journal of heterocyclic chemistry, 30(2), 1993, pp. 357-359
Citations number
17
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Journal of heterocyclic chemistry → ACNP
ISSN journal
0022152X
Volume
30
Issue
2
Year of publication
1993
Pages
357 - 359
Database
ISI
SICI code
0022-152X(1993)30:2<357:PON1BC>2.0.ZU;2-H
Abstract
The preparation of 1,2,4-thiadiazoles with a di-tert-butylphenol subst ituent at the thiadiazole 3-position is described. A thermally generat ed nitrile sulfide was reacted with tosyl cyanide in a 1,3-dipolar cyc lization reaction to provide a thiadiazole intermediate containing a l abile 5-tosyl substituent.