A. Alberola et al., THE REACTIVITY OF 3-METHYL-5-PHENYLISOTHIAZOLE WITH CARBONYL-COMPOUNDS, Journal of heterocyclic chemistry, 30(2), 1993, pp. 393-396
The reactivity of 3-methyl-5-phenylisothiazole with carbonyl compounds
in the presence of n-butyllithium and the system lithium cyclohexylam
ide-NN,N',N'-tetramethylethylendiamine (LICA-TMEDA) is studied. n-Buty
llithium is found to lead to higher yields of the hydroxy derivatives
of the isothiazole compound than LICA-TMEDA. Ring opening products are
not detected under the reaction conditions used.