THE REACTIVITY OF 3-METHYL-5-PHENYLISOTHIAZOLE WITH CARBONYL-COMPOUNDS

Authors
ALBEROLA A CALVO L RODRIGUEZ MTR SANUDO MC
Citation
A. Alberola et al., THE REACTIVITY OF 3-METHYL-5-PHENYLISOTHIAZOLE WITH CARBONYL-COMPOUNDS, Journal of heterocyclic chemistry, 30(2), 1993, pp. 393-396
Citations number
13
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Journal of heterocyclic chemistry → ACNP
ISSN journal
0022152X
Volume
30
Issue
2
Year of publication
1993
Pages
393 - 396
Database
ISI
SICI code
0022-152X(1993)30:2<393:TRO3WC>2.0.ZU;2-5
Abstract
The reactivity of 3-methyl-5-phenylisothiazole with carbonyl compounds in the presence of n-butyllithium and the system lithium cyclohexylam ide-NN,N',N'-tetramethylethylendiamine (LICA-TMEDA) is studied. n-Buty llithium is found to lead to higher yields of the hydroxy derivatives of the isothiazole compound than LICA-TMEDA. Ring opening products are not detected under the reaction conditions used.