A. Alberola et al., SYNTHESIS OF 3-SUBSTITUTED 5-ARYLISOXAZOLES FROM ALPHA,BETA-UNSATURATED OXIMES, Journal of heterocyclic chemistry, 30(2), 1993, pp. 467-471
The synthesis of 3-substituted 5-arylisoxazoles from oximes of alpha,b
eta-unsaturated ketones is studied. The formation of the isoxazole der
ivatives takes place by cyclization of oximes in the presence of iodin
e and potassium iodide. The presence of isoxazoline is detected. On th
e basis of the results a plausible mechanism is suggested.