ANTICANCER ANTHRAPYRAZOLES - THE SYNTHESIS OF 2-SUBSTITUTED 5-NITRO AND 5-AMINOANTHRA[1,9-CD]PYRAZOL-6(2H)-ONES

Authors
SHOWALTER HDH TURNER WR
Citation
Hdh. Showalter et Wr. Turner, ANTICANCER ANTHRAPYRAZOLES - THE SYNTHESIS OF 2-SUBSTITUTED 5-NITRO AND 5-AMINOANTHRA[1,9-CD]PYRAZOL-6(2H)-ONES, Journal of heterocyclic chemistry, 30(2), 1993, pp. 493-496
Citations number
24
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Journal of heterocyclic chemistry → ACNP
ISSN journal
0022152X
Volume
30
Issue
2
Year of publication
1993
Pages
493 - 496
Database
ISI
SICI code
0022-152X(1993)30:2<493:AA-TSO>2.0.ZU;2-Q
Abstract
Synthetic methodologies for the preparation of substituted 5-nitro- an d 5-aminoanthra[1,9-cd]-pyrazol-6(2H)-ones, 4 and 5 respectively, subs tituted with a basic side at N-2 and dioxy substitution in the A-ring, are reported. These compounds are essentially devoid of activity agai nst in vitro L1210 leukemia and in vivo murine P388 leukemia.