THE CHLOROMETHYLATION OF CODEINE - ISOLATION OF A QUATERNARY IODIDE

Authors
GRANT AD ZACHARIAS DE MASCAVAGE LM KEMMERER GE DALTON DR
Citation
Ad. Grant et al., THE CHLOROMETHYLATION OF CODEINE - ISOLATION OF A QUATERNARY IODIDE, Journal of heterocyclic chemistry, 30(2), 1993, pp. 553-557
Citations number
14
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Journal of heterocyclic chemistry → ACNP
ISSN journal
0022152X
Volume
30
Issue
2
Year of publication
1993
Pages
553 - 557
Database
ISI
SICI code
0022-152X(1993)30:2<553:TCOC-I>2.0.ZU;2-B
Abstract
A single N-chloromethylcodinium iodide has been isolated from the reac tion of chloroiodomethane with codeine. Complete proton and carbon nmr and X-ray analyses dictate that this stable material bears the chloro methyl group axial. It is identical (except for the anion) to one of t he salts obtained on long term storage of codeine in dichloromethane.