NEW HORIZONS IN THE TREATMENT OF MULTIPLE-SCLEROSIS

Objective: To review and discuss novel therapeutic approaches to multi ple sclerosis (MS), particularly strategies designed to modulate immun opathogenetic mechanisms. Data sources: Recent medical and scientific publications and the proceedings of recent conferences in Australia an d the United States. Conclusions: Clearer understanding of the pathoge netic mechanisms leading to inflammation and demyelination in MS is su ggesting new strategies for intervention. Both antigen-specific and no n-antigen-specific immunomodulation can be achieved in animal models, and human clinical trials of several new agents can be expected shortl y.