Epididymitis is common, yet it is rarely associated with fungal pathog
ens. We report a case of Candida albicans epididymitis in a diabetic w
hich was ultimately treated by orchiectomy. Opportunistic infections o
f the genitourinary tract in immunosuppressed patients are becoming mo
re prevalent; examples include fungal infections in patients with acqu
ired immune deficiency syndrome or after organ transplant. The fact th
at opportunistic organisms can invade the epididymis and produce infec
tion suggests that in cases of persistent epididymitis, which have fai
led to respond to conventional therapy, more aggressive diagnostic pro
cedures should be considered. Needle aspiration with cultures for fung
us and viral organisms should be performed. This is especially true in
patients with preexisting chronic illness or an immune compromised st
ate.