Computed tomography (CT) is an excellent imaging modality for demonstr
ating the size, shape, and position of the spleen, as well as for depi
cting intrasplenic pathologic features. However, it has limited value
in the diagnosis of splenic involvement by lymphoma. Greater accuracy
in diagnosing splenic lymphoma may be obtained by demonstrating adenop
athy in the splenic hilum or by showing focal splenic defects, in addi
tion to splenomegaly. In discussing the normal anatomy of the spleen,
congenital variations (eg, accessory spleen, polysplenia, asplenia, an
d wandering spleen), and acquired abnormalities such as those resultin
g from trauma, infection, infarction, cysts, and neoplasms, this artic
le provides evidence that CT is valuable in showing a wide variety of
splenic variations and abnormalities while simultaneously allowing eva
luation of the remaining intraabdominal structures. The cases presente
d demonstrate both the value and limitations of CT in the examination
of patients with congenital and acquired abnormalities of the spleen.