GLYCINE REDUCES EARLY RENAL PARENCHYMAL UPTAKE OF CISPLATIN

Glycine reduces early renal parenchymal uptake of cisplatin. We evalua ted the effect of glycine infusions on the early renal uptake of cispl atin, measured one hour after cisplatin was injected, as well as five days following cisplatin administration. Glycine (1.25 mmol per 100 g body wt) markedly attenuated the early uptake of platinum by the kidne y, an effect not observed with control infusions of saline or of L-ala nine. The kidney content of platinum at five days, on the other hand, was similar in glycine-treated animals and saline controls. Early inhi bition of renal uptake of platinum may be responsible for glycine's pr otective action in experimental cisplatin nephrotoxicity.