THE EMBRYONIC GAMMA-SUBUNIT OF THE NICOTINIC ACETYLCHOLINE-RECEPTOR IS EXPRESSED IN ADULT EXTRAOCULAR-MUSCLE

Authors
HORTON RM MANFREDI AA CONTITRONCONI BM
Citation
Rm. Horton et al., THE EMBRYONIC GAMMA-SUBUNIT OF THE NICOTINIC ACETYLCHOLINE-RECEPTOR IS EXPRESSED IN ADULT EXTRAOCULAR-MUSCLE, Neurology, 43(5), 1993, pp. 983-986
Citations number
20
Categorie Soggetti
Clinical Neurology
Journal title
Neurology → ACNP
ISSN journal
00283878
Volume
43
Issue
5
Year of publication
1993
Pages
983 - 986
Database
ISI
SICI code
0028-3878(1993)43:5<983:TEGOTN>2.0.ZU;2-4
Abstract
We have PCR-amplified cDNA sequence of the 'embryonic'' gamma subunit of muscle acetylcholine receptor (AChR) from adult bovine extraocular muscle (EOM). We cloned and sequenced this product and used it to prob e Northern blots. We detected the gamma subunit in EOM mRNA, but not i n control skeletal muscle. The presence of gamma subunit in EOMs may e xplain their preferential involvement in myasthenia gravis, where an a utoimmune response to the gamma subunit is generally present.