Objective: To determine the prevalence and clinical manifestations of
trichomoniasis among sexually active men. Design: Survey of two groups
of men attending a sexually transmitted disease clinic. Subjects had
a comprehensive sexual history and clinical examination plus cultures
for Trichomonas vaginalis, Neisseria gonorrhoeae, and Chlamydia tracho
matis. Participants: The study included 147 sexual partners of women w
ith trichomoniasis and 300 subjects selected randomly from heterosexua
l men coming to the same clinic for evaluation of new problems. Main O
utcome Measures: Isolation of T. vaginalis was compared with urogenita
l signs and symptoms. Results: The prevalence of T. vaginalis was 33 o
f 147 (22% [95% CI, 16% to 29%]) among sexual contacts of women with t
richomoniasis and 17 of 300 (6% [CI, 3% to 9%]) among heterosexual men
attending the same clinic. Men with trichomoniasis alone were more li
kely to complain of urethral discharge (P < 0.01), to have discharge o
n examination (P < 0.03), and to have inflammatory cells in their uret
hral secretions (P < 0.01) than were men who did not have T. vaginalis
, N. gonorrhoeae, or C. trachomatis. Trichomonas vaginalis remained as
sociated with nongonococcal nonchlamydial urethritis (adjusted odds ra
tio 3.8; CI, 1.1 to 11.2) after adjustment for race, age, number of se
x partners in the previous 6 months, exposure to a partner with tricho
moniasis, and history of trichomoniasis, urethritis, or gonorrhea. Con
clusions: Trichomoniasis was common among men at risk for sexually tra
nsmitted diseases and was associated with symptoms and signs of urethr
itis.