CAPILLARY ZONE ELECTROPHORESIS AND MICELLAR ELECTROKINETIC CAPILLARY CHROMATOGRAPHY OF SOME NONSTEROIDAL ANTIINFLAMMATORY DRUGS (NSAIDS)

The possibilities of capillary electrophoresis (CE) and micellar elect rokinetic capillary chromatography (MEKC) were investigated for the qu alitative analysis of some non-steroidal antiinflammatory drugs. In CE the influence of the pH of the buffer and its ionic strength were inv estigated for a test mixture of six compounds. Also the influence of o rganic modifiers was studied. The best conditions were applied to the separation of 15 drugs. In MEKC the influence of the concentration of SDS in buffers with pH ranges of 8.0-9.0 was investigated. The influen ce of an organic modifier, namely acetonitrile was discussed, whereby an interesting phenomenon of change in retention behaviour was noted. A combination of CE and MEKC allows the separation of the 15 above-men tioned compounds and forms an interesting alternative to HPLC.