Jre. Moraes et al., PARTICIPATION OF MACROPHAGES IN CHLORAMPHENICOL-POTENTIATED CARRAGEENAN-INDUCED PERITONITIS IN RATS, Brazilian journal of medical and biological research, 26(5), 1993, pp. 497-507
1. We investigated the possible potentiating effect of chloramphenicol
succinate (30 mg/kg, every 12 h for 4 days, ip) on the response of po
lymorphonuclear neutrophils to carrageenin (150 mug, ip) or dextran (1
00 mug, ip) in the peritoneal cavity of male Wistar rats (180-230 g; N
= 12 in each group). 2. Chloramphenicol potentiated the cell migratio
n induced by carrageenin (35%) but not that induced by dextran. Previo
us macrophage depletion in the peritoneal cavity by washing with steri
le saline abolished the cell response, whereas a previous thioglycolla
te-induced increase in macrophage numbers enhanced the potentiating ef
fect (60%). 3. These results suggest that the potentiating effect on p
olymorphonuclear neutrophil migration induced by chloramphenicol may b
e related to chemotactic factors released by macrophages.