PARTICIPATION OF MACROPHAGES IN CHLORAMPHENICOL-POTENTIATED CARRAGEENAN-INDUCED PERITONITIS IN RATS

Citation
Jre. Moraes et al., PARTICIPATION OF MACROPHAGES IN CHLORAMPHENICOL-POTENTIATED CARRAGEENAN-INDUCED PERITONITIS IN RATS, Brazilian journal of medical and biological research, 26(5), 1993, pp. 497-507
Citations number
33
Categorie Soggetti
Medicine, Research & Experimental
ISSN journal
0100879X
Volume
26
Issue
5
Year of publication
1993
Pages
497 - 507
Database
ISI
SICI code
0100-879X(1993)26:5<497:POMICC>2.0.ZU;2-J
Abstract
1. We investigated the possible potentiating effect of chloramphenicol succinate (30 mg/kg, every 12 h for 4 days, ip) on the response of po lymorphonuclear neutrophils to carrageenin (150 mug, ip) or dextran (1 00 mug, ip) in the peritoneal cavity of male Wistar rats (180-230 g; N = 12 in each group). 2. Chloramphenicol potentiated the cell migratio n induced by carrageenin (35%) but not that induced by dextran. Previo us macrophage depletion in the peritoneal cavity by washing with steri le saline abolished the cell response, whereas a previous thioglycolla te-induced increase in macrophage numbers enhanced the potentiating ef fect (60%). 3. These results suggest that the potentiating effect on p olymorphonuclear neutrophil migration induced by chloramphenicol may b e related to chemotactic factors released by macrophages.