SINONASAL ADENOCARCINOMA - EPIDEMIOLOGIC AND CLINICOPATHOLOGICAL STUDY OF 34 CASES

Thirty-four cases of sino-nasal adenocarcinoma treated between 1976 an d 1992 are presented. The purpose of this work is the epidemiological analysis of this disease and to put forward a classification of the le sions according to their degree of differentiation, based on the histo pathological examination of 29 tumors. The risk increase of having a s ino-nasal neoplasia was significant in the population exposed to wood dust in their working environment - 896 times greater (540 in the male population) for adenocarcinoma and 20 times greater for squamous-cell adenocarcinoma. The proposed histopathological classification divides these lesions according to their degree of differentiation. In this s eries 23 well-differentiated cases were found, three moderately differ entiated and three colloid-type. The five-year determinate survival of this series was 30%. The tumor stage (especially intracranial involve ment) was the only significant clinico-pathological parameter that imp aired the survival.