INFLUENCE OF THE ELECTRICAL-STIMULATION OF THE MEDIAL AMYGDALA ON ADRENOCORTICAL SENSITIVITY TO ADRENOCORTICOTROPIN IN HYPOPHYSECTOMIZED RATS

Authors
SAITO H SATO T KABA H OKUTANI F YU GZ SETO K KIMURA F KAWAKAMI M ROBERTS S
Citation
H. Saito et al., INFLUENCE OF THE ELECTRICAL-STIMULATION OF THE MEDIAL AMYGDALA ON ADRENOCORTICAL SENSITIVITY TO ADRENOCORTICOTROPIN IN HYPOPHYSECTOMIZED RATS, Experimental and clinical endocrinology, 100(3), 1992, pp. 145-147
Citations number
13
Categorie Soggetti
Endocrynology & Metabolism
Journal title
Experimental and clinical endocrinology → ACNP
ISSN journal
02327384
Volume
100
Issue
3
Year of publication
1992
Pages
145 - 147
Database
ISI
SICI code
0232-7384(1992)100:3<145:IOTEOT>2.0.ZU;2-G
Abstract
The effects of electrical stimulation of medial amygdala on the adreno cortical sensitivity to adrenocorticotrophin (ACTH) were investigated in hypophysectomized rats. The intravenous injection of ACTH increased the rates of C-14 transfer from C-14-1-acetate into corticosterone an d cortisol in the adrenal slices of hypophysectomized rats. The electr ical stimulation of the medial amygdala produced a further increase in the rates of C-14 transfer from C-14-1-acetate into corticosterone an d cortisol. From these results, it might be suggested that the medial amygdala was capable of enhancing the adrenocortical steroidogenesis i n response to ACTH.