E. Arnauld et al., FUNCTIONAL-HETEROGENEITY OF THE CAUDATE-PUTAMEN AS REVEALED BY C-FOS INDUCTION IN RESPONSE TO D1 RECEPTOR ACTIVATION, Molecular brain research, 18(4), 1993, pp. 339-342
SKF 38 393, a dopamine receptor agonist which stimulates the D1 recept
or, has been shown to activate c-fos to a detectable level in rats onl
y when the striatum has been sensitized by a previous 6-OHDA lesion of
the nigrostriatal tract. In the present study, we reexamine the effec
t of SKF 38 393 by in situ hybridization in non-lesioned mice and show
an induction of c-fos mRNA which is restricted to the ventricular edg
e and to the caudal part of the caudoputamen (CP) even with large dose
s of SKF 38 393. These results suggest a functional heterogeneity in t
he CP in response to dopaminergic drugs, which could reflect the anato
mical or neurochemical heterogeneity of the striatum itself and its ne
uroanatomical connections.