Mc. Winslet et al., THE INFLUENCE OF ILEAL POUCH-ANAL ANASTOMOSIS FOR ULCERATIVE-COLITIS ON ILEAL GLYCOPROTEIN-SYNTHESIS, Scandinavian journal of gastroenterology, 28(6), 1993, pp. 500-502
Restorative proctocolectomy and ileal pouch-anal anastomosis are frequ
ently associated with the onset of low-grade inflammation, colonic met
aplasia, and pouchitis. The influence of intestinal adaptation and inf
lammatory activity on ileal glycoprotein synthesis (GS) has been asses
sed. Ileal GS activity in controls (n = 13, 28.9 +/- 3.6) was similar
to that of patients with ulcerative colitis (n = 18, 26.4 +/- 3.6) irr
espective of the presence of backwash ileitis (n = 6, 22.0 +/- 4.0). I
leoanal pouch construction was not associated with a significant chang
e in ileal GS activity regardless of the presence of low-grade inflamm
ation (n = 19, 25.9 +/- 2.2), frank pouchitis (n = 5, 24.4 +/- 4.6), o
r transformation to a colonic type of mucosa (n = 6, 25.4 +/- 5.2). Th
e transformation of ileal mucosa from an absorptive to a storage funct
ion is associated with characteristic morphologic and inflammatory cha
nges but does not produce a protective response mediated by increased
GS.