INACTIVATION OF RIFAMPIN BY NOCARDIA-BRASILIENSIS

Authors
YAZAWA K MIKAMI Y MAEDA A AKAO M MORISAKI N IWASAKI S
Citation
K. Yazawa et al., INACTIVATION OF RIFAMPIN BY NOCARDIA-BRASILIENSIS, Antimicrobial agents and chemotherapy, 37(6), 1993, pp. 1313-1317
Citations number
21
Categorie Soggetti
Pharmacology & Pharmacy",Microbiology
Journal title
Antimicrobial agents and chemotherapy → ACNP
ISSN journal
00664804
Volume
37
Issue
6
Year of publication
1993
Pages
1313 - 1317
Database
ISI
SICI code
0066-4804(1993)37:6<1313:IORBN>2.0.ZU;2-L
Abstract
Rifampin was glycosylated by a pathogenic species of Nocardia, i.e., N ocardia brasiliensis. The structures of two glycosylated, compounds (R IP-1 and RIP-2) isolated from the culture broth of the bacterium were determined to be 3-formyl-23-(O-[beta-D-glucopyranosyl])rifamycin SV a nd 23-(O-[beta-D-glucopyranosyl])rifampin, respectively. Both compound s lacked antimicrobial activity against other gram-positive bacteria a s well as the Nocardia species.