EFFICACY OF (-)-9-[4-HYDROXY-2-(HYDROXYMETHYL)BUTYL]GUANINE IN AFRICAN-GREEN MONKEYS INFECTED WITH SIMIAN VARICELLA VIRUS

Authors
SOIKE KF BOHM R HUANG JL OBERG B
Citation
Kf. Soike et al., EFFICACY OF (-)-9-[4-HYDROXY-2-(HYDROXYMETHYL)BUTYL]GUANINE IN AFRICAN-GREEN MONKEYS INFECTED WITH SIMIAN VARICELLA VIRUS, Antimicrobial agents and chemotherapy, 37(6), 1993, pp. 1370-1372
Citations number
12
Categorie Soggetti
Pharmacology & Pharmacy",Microbiology
Journal title
Antimicrobial agents and chemotherapy → ACNP
ISSN journal
00664804
Volume
37
Issue
6
Year of publication
1993
Pages
1370 - 1372
Database
ISI
SICI code
0066-4804(1993)37:6<1370:EO(IA>2.0.ZU;2-4
Abstract
(-)-9-[4-Hydroxy-2-(hydroxymethyl)butyl]guanine was evaluated for its efficacy in African green monkeys infected with simian varicella virus . Treatment by intramuscular injection was initiated 48 h after virus inoculation and was continued for 10 days; the treatment showed therap eutic effects on rash and viremia at dosages down to 1 mg/kg of body w eight per day.