Xy. Zhou et al., ROLE OF CEPHALOSPORINASE IN CARBAPENEM RESISTANCE OF CLINICAL ISOLATES OF PSEUDOMONAS-AERUGINOSA, Antimicrobial agents and chemotherapy, 37(6), 1993, pp. 1387-1389
With numerous imipenem-resistant clinical isolates of Pseudomonas aeru
ginosa as well as in vitro-selected resistant mutants, we have demonst
rated, by,a simple method with a powerful cephalosporinase inhibitor,
BRLA2715, the contribution of chromosomal cephalosporinase in resistan
ce to imipenem in this species.