CLONING OF THE CDNA CODING FOR RAT-BRAIN CMP-NEUAC-CD3 ALPHA-2-8 SIALYLTRANSFERASE

Authors
ZENG GC GAO LY YU RK
Citation
Gc. Zeng et al., CLONING OF THE CDNA CODING FOR RAT-BRAIN CMP-NEUAC-CD3 ALPHA-2-8 SIALYLTRANSFERASE, Gene, 187(1), 1997, pp. 131-134
Citations number
19
Categorie Soggetti
Genetics & Heredity
Journal title
Gene → ACNP
ISSN journal
03781119
Volume
187
Issue
1
Year of publication
1997
Pages
131 - 134
Database
ISI
SICI code
0378-1119(1997)187:1<131:COTCCF>2.0.ZU;2-3
Abstract
The cDNA coding for GT3-synthase has been cloned from a rat fetal brai n cDNA library. The complete nucleotide sequence and the deduced amino acid sequence of the rat GT3-synthase cDNA were highly homologous to those of the mouse GT3-synthase. Quantitative RT-PCR showed that, as a key enzyme for the synthesis of 'c'-series gangliosides, the expressi on of GT3-synthase was developmentally regulated in embryonic rat brai ns.