A CLINICAL-STUDY MONITORING LOW-INTENSITY ANTICOAGULANT-THERAPY WITH A STANDARD-SENSITIVITY THROMBOPLASTIN

Citation
Mt. Brophy et al., A CLINICAL-STUDY MONITORING LOW-INTENSITY ANTICOAGULANT-THERAPY WITH A STANDARD-SENSITIVITY THROMBOPLASTIN, Archives of pathology and laboratory medicine, 117(6), 1993, pp. 618-621
Citations number
21
Categorie Soggetti
Pathology,"Medical Laboratory Technology","Medicine, Research & Experimental
Journal title
Archives of pathology and laboratory medicine
ISSN journal
00039985 → ACNP
Volume
117
Issue
6
Year of publication
1993
Pages
618 - 621
Database
ISI
SICI code
0003-9985(1993)117:6<618:ACMLAW>2.0.ZU;2-P
Abstract
The ability of the prothrombin time to measure the anticoagulant effec t of warfarin sodium varies depending on the particular tissue thrombo plastin used in performing the test. Based on studies using sensitive thromboplastins, lower therapeutic ranges of anticoagulation are recom mended. The adequacy of monitoring therapy in this lower range with th e relatively insensitive thromboplastins commonly used in North Americ a is unestablished. This 16-month prospective study used a standard No rth American thromboplastin to monitor 157 anticoagulated patients tre ated in a low therapeutic range. Of the 1734 prothrombin times generat ed, 876 (56%) were therapeutic, with 400 (23%) below and 458 (26%) abo ve the therapeutic range. These results are comparable with those publ ished in trials in which more sensitive thromboplastins were used in a similar therapeutic range. We conclude that standard North American t hromboplastins are adequately suited to monitor therapy in this lower range.