EFFECT OF ACETYL-L-CARNITINE ON 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE (MPTP) NEUROTOXICITY

Authors
HARIK SI HRITZ MA
Citation
Si. Harik et Ma. Hritz, EFFECT OF ACETYL-L-CARNITINE ON 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE (MPTP) NEUROTOXICITY, Biochemical pharmacology, 45(10), 1993, pp. 2170-2172
Citations number
17
Categorie Soggetti
Pharmacology & Pharmacy",Biology
Journal title
Biochemical pharmacology → ACNP
ISSN journal
00062952
Volume
45
Issue
10
Year of publication
1993
Pages
2170 - 2172
Database
ISI
SICI code
0006-2952(1993)45:10<2170:EOAO1>2.0.ZU;2-3
Abstract
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) is believed to ind uce neurotoxicity by inhibiting mitochondrial oxidative metabolism whe reas acetyl-L-carnitine (ALC) facilitates this process by transporting fatty acids into mitochondria for beta oxidation. We investigated whe ther large doses of ALC given by gavage for 1 week before and 1 week a fter MPTP could ameliorate MPTP neurotoxicity in mice. We found that A LC had no effect on MPTP-induced depletion of striatal dopamine and it s metabolites.