PREVENTION AND TREATMENT OF NONSTEROIDAL GASTRODUODENAL LESIONS

Strategies for the prophylaxis and therapy of non-steroidal anti-infla mmatory drug- (NSAID) induced gastroduodenal lesions include: drugs wh ich reduce the hydrogenic intragastric concentration, for example, H-2 -receptor antagonists, antacids and proton pump inhibitors; site and c ytoprotective drugs, and synthetic prostaglandins. Available data sugg est that established duodenal and small gastric ulcers usually heal wi th various therapeutic regimens despite continued NSAID use. In this r eview, we consider the effects of the agents mentioned above in the he aling of NSAID-induced lesions.