THE EFFECT OF ADRENALECTOMY ON THE CIRCADIAN VARIATION IN THE RATE OFKINDLED SEIZURE DEVELOPMENT

Citation
G. Weiss et al., THE EFFECT OF ADRENALECTOMY ON THE CIRCADIAN VARIATION IN THE RATE OFKINDLED SEIZURE DEVELOPMENT, Brain research, 612(1-2), 1993, pp. 354-356
Citations number
28
Categorie Soggetti
Neurosciences
Journal title
ISSN journal
00068993
Volume
612
Issue
1-2
Year of publication
1993
Pages
354 - 356
Database
ISI
SICI code
0006-8993(1993)612:1-2<354:TEOAOT>2.0.ZU;2-U
Abstract
The hypothalamic-pituitary adrenal axis (HPAA) is activated during kin dled seizures and the circadian changes in this axis may contribute to the circadian variation in the kindling rate. Changes in the rate of seizure development were examined in rats that were amygdala kindled i n the a.m., at midday and in the p.m.. Sham operated control groups we re compared to adrenalectomized groups. Adrenalectomy had no effect on the midday rate but abolished the normal circadian variation by accel erating the rate in the a.m. and decreasing the rate in the p.m.. Thes e results suggest a complicated relationship of kindled seizure rate t o the hormones of the HPAA axis.