G. Weiss et al., THE EFFECT OF ADRENALECTOMY ON THE CIRCADIAN VARIATION IN THE RATE OFKINDLED SEIZURE DEVELOPMENT, Brain research, 612(1-2), 1993, pp. 354-356
The hypothalamic-pituitary adrenal axis (HPAA) is activated during kin
dled seizures and the circadian changes in this axis may contribute to
the circadian variation in the kindling rate. Changes in the rate of
seizure development were examined in rats that were amygdala kindled i
n the a.m., at midday and in the p.m.. Sham operated control groups we
re compared to adrenalectomized groups. Adrenalectomy had no effect on
the midday rate but abolished the normal circadian variation by accel
erating the rate in the a.m. and decreasing the rate in the p.m.. Thes
e results suggest a complicated relationship of kindled seizure rate t
o the hormones of the HPAA axis.