A 3 COMPARTMENT OPEN MODEL WITH 2 TIME LAGS

Authors
CHERRUAULT Y SARIN VB
Citation
Y. Cherruault et Vb. Sarin, A 3 COMPARTMENT OPEN MODEL WITH 2 TIME LAGS, International journal of bio-medical computing, 32(3-4), 1993, pp. 269-277
Citations number
8
Categorie Soggetti
Mathematical Methods, Biology & Medicine","Computer Applications & Cybernetics","Engineering, Biomedical
Journal title
International journal of bio-medical computing → ACNP
ISSN journal
00207101
Volume
32
Issue
3-4
Year of publication
1993
Pages
269 - 277
Database
ISI
SICI code
0020-7101(1993)32:3-4<269:A3COMW>2.0.ZU;2-P
Abstract
The present study deals with the identification of exchange parameters involved in a three-compartment open model with two time lags in whic h elimination occurs from the central compartment. Two different optim ization methods have been used which involve the reduction of differen t unknowns to a single variable theta, with the help of Archimedes Spi ral. Thus, the solution requires the global minimum of a functional of single variable theta. Results are compared with those obtained by th e generalized least square method.