2-CHLORO-2' DEOXYADENOSINE PREVENTS ANGIOPATHIC CHANGES IN CEREBRAL-ARTERIES IN EXPERIMENTAL SAH IN RABBITS

We compared the morphology of the basilar artery walls in rabbits with experimental subarachnoid haemorrhage (SAH) without and with concomit ant treatment with a novel immunosuppressive drug, 2-chloro-2'-deoxyad enosine (2 CdA). The treatment was successful in the prevention of the angiopathic changes, most likely due to its ability to inhibit lympho cyte activation in response to mitogenic signals. Since lymphocyte (an d monocyte?) activation may play an important role in the development of the delayed neurological deficits in patients following SAH, the us e of 2 CdA to prevent these deficits shall be considered.