PHENOTYPES OF MONONUCLEAR CELL INFILTRATES IN HUMAN CENTRAL-NERVOUS-SYSTEM

Using a panel of monoclonal antibodies applicable for identification o f cell types in paraffin sections, the prevalence of mononuclear cell infiltrates with different phenotypes was estimated in large areas tak en from 11 cases of acute and chronic inflammatory diseases in the hum an central nervous system. The present study clearly demonstrated a di versity of inflammatory mononuclear cell infiltrates, and the dominanc e of cell types in individual lesions appeared to be determined by bot h the nature of the diseases and the age of the lesions. The possible pathognomonic significance of a relatively high prevalence of CD4+CD45 RO+ lymphocytes in acute rabies and in a convalescent stage of Japanes e encephalitis and subacute sclerosing panencephalitis is discussed.