An association between coffee drinking and cancer of the lower urinary
tract (LUT) was first suggested 20 years ago and has been the subject
of many epidemiological studies. We have undertaken a critical review
and statistical summary of 35 case-control studies of this associatio
n published between 1971 and 1992. Predefined methodological criteria
were applied to the available reports. Studies were classified as eith
er meeting the criteria (core studies) or failing to satisfy at least
one of the requirements for design or analysis (non-core studies). The
summarised data from the 8 core studies showed no evidence of an incr
ease in risk of LUT cancer with coffee drinking in men or women after
adjustment for the effects of cigarette smoking (odds ratio 1.07 [95%
CI 1.00-1.14] for men, 0.91 [0.81-1.03] for women). The measures of as
sociation from the non-core studies were higher on average than those
from the core studies, although the inclusion of these data in an over
all summarised estimate did not substantially change the findings from
the core analysis. We conclude that the best available data do not su
ggest a clinically important association between the regular use of co
ffee and development of cancer of the LUT in men or women.