REPAIR OF THE TRANSECTED RAT SCIATIC-NERVE - MATRIX FORMATION WITHIN IMPLANTED SILICONE TUBES

Matrix formation within silicone tubes of different geometries implant ed between the stumps of the transected rat sciatic nerve was studied. A matrix, composed of longitudinally oriented fibrin strands containi ng fibronectin, was formed within one day. The matrix then increased i n size. The matrix contained macrophages and other inflammatory cells. Matrix size could be increased if the diameter of the tube was increa sed or if holes were made in the implanted tube. In contrast, matrix d iameter decreased if the tube length was increased or if circulation w as compromised in the inserts. The results suggest that the size, orie ntation and cellular components of the matrix have profound effects on the regenerative response of the transected nerve.