C. Vecchio et al., EVALUATION OF TIME-TEMPERATURE PARAMETER EFFECTS ON THE STRUCTURAL CHARACTERISTICS OF FILMS OBTAINED BY AQUEOUS POLYMERIC DISPERSIONS, Drug development and industrial pharmacy, 23(4), 1997, pp. 345-349
Pellet cores, containing d-indobufen as the active principle, were pre
pared by the extrusion-spheronization process and coated with an aqueo
us polymeric dispersion using Wurster bottom-spray equipment. The pres
ent study investigated factors affecting the film properties, such as
the product temperature during the coating process and the effects of
the thermal postcoating treatment (curing phase), carried out in diffe
rent drying conditions. The experimental results, in terms of drug rel
ease control, confirm that the properties of the film coating depend o
n the substrate temperature, which directly influences the coalescence
process of the polymeric dispersion. Moreover, along with time and te
mperature of the drying phase, the type of equipment used affects the
performance of the film coating dosage form. In particular, using the
fluidized bed at a high temperature for a short time produced a film c
oating structure that seemed to remain unchanged after storage.