DISSOLUTION BEHAVIOR OF OXAZEPAM IN PRESENCE OF CYCLODEXTRINS - EVALUATION OF OXAZEPAM-DIMEB BINARY-SYSTEM

The inclusion complex formation between oxazepam (Ox) and heptakis (2, 6-di-O-methyl)-beta-cyclodextrin (DIMEB) was studied in solution by so lubility and ultraviolet spectroscopy methods, and in the solid state by differential scanning calorimetry, scanning electron microscopy, an d powder x-ray diffractometry. The apparent stability constant, K-c, c alculated by solubility and spectral data, was estimated as 642 and 58 8 M(-1), respectively. The solid complexes have been prepared by knead ing and spray-drying techniques. The dissolution rate studies reveal t hat the better dissolution behavior corresponded to the spray-dried sy stems.